Sridhara, T. S. ; Swarupa, G. ; Khar, Ashok (1993) Downregulation of phospho-tyrosine phosphatases in a macrophage tumor FEBS Letters, 326 (1-3). pp. 75-79. ISSN 0014-5793
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0014-5793(93)81764-Q
Abstract
We provide evidence for the downregulation of phospho-tyrosine phosphatases (PTPases) in malignancy. AK-5, a rat macrophage tumor, shows the downregulation of the transcripts of two non-receptor-type PTPases, PTP-1 and PTP-S. Though downregulated fourfold, the genomic organization of PTP-S is unaltered. There is no gross alteration of the PTPase activity in AK-5 as compared to macrophages. Immunoblot analysis reveals no significant change in the total phospho-tyrosine levels in AK-5, but there is a qualitative difference in the pattern between AK-5 and macrophages. Our results lend credence to the conjecture that PTPases also might be involved in malignancy.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Phospho-tyrosine Phosphatase; Downregulation; Malignancy; Rat Macrophage Cell Line |
| ID Code: | 55935 |
| Deposited On: | 19 Aug 2011 07:54 |
| Last Modified: | 19 Aug 2011 07:54 |
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