Enantioselective turnover in glyoxylate-ene reactions catalyzed by chiral copper complexes

Pandey, Manoj K. ; Bisai, Alakesh ; Singh, Vinod K. (2006) Enantioselective turnover in glyoxylate-ene reactions catalyzed by chiral copper complexes Tetrahedron Letters, 47 (6). pp. 897-900. ISSN 0040-4039

Full text not available from this repository.

Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.tetlet.2005.11.159

Abstract

The catalytic, enantioselective carbonyl-ene reaction of ethyl glyoxylate with α-methylstyrene and 4-halo-α-methylstyrene has been investigated in the presence of copper triflate–bisoxazoline complexes. The reaction proceeded smoothly to give γ,δ-unsaturated-α-hydroxy esters in moderate to good yields and with excellent enantioselectivity (up to 100% ee). A hypothesis has been provided to explain the reversal of enantioselectivity in the reaction.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:55407
Deposited On:18 Aug 2011 08:43
Last Modified:18 Aug 2011 08:43

Repository Staff Only: item control page