Japanese encephalitis: development of new candidate vaccines

Bharati, Kaushik ; Vrati, Sudhanshu (2006) Japanese encephalitis: development of new candidate vaccines Expert Review of Anti-infective Therapy, 4 (2). pp. 313-324. ISSN 1478-7210

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Official URL: http://www.expert-reviews.com/doi/abs/10.1586/1478...

Related URL: http://dx.doi.org/10.1586/14787210.4.2.313

Abstract

Japanese encephalitis (JE) is the most common form of viral encephalitis that appears in the form of frequent epidemics of brain fever throughout Southeast Asia, China and India. The disease is caused by a Flavivirus named Japanese encephalitis virus that is spread to humans by mosquitoes. An internationally approved mouse brain-derived inactivated vaccine has been available that is relatively expensive, gives immunity of uncertain duration and is not completely safe. Cell culture-derived inactivated and attenuated JE vaccines are in use in China, but these are not produced as per the norms acceptable in most countries. Several new promising JE vaccine candidates have been developed, some of which are under different stages of clinical evaluation. These new candidate JE vaccines have the potential to generate long-lasting immunity at low cost.

Item Type:Article
Source:Copyright of this article belongs to Expert Reviews.
Keywords:Immunogenicity; Peptide; Recombinant Virus; Virus-like Particle
ID Code:55147
Deposited On:18 Aug 2011 07:35
Last Modified:18 Aug 2011 07:35

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