FMR1 haplotype analysis among Indian communities

Abstract

Objective: To analyse fragile X mental retardation 1 haplotypes among non-fragile X males from different Indian caste-based communities in order to enable inter-community comparisons to be made and permit wider comparisons with other ethnic groups. Subjects and Methods: Males (n = 124) from four major Hindu castes (Brahmins, Kshatriyas, Vaishyas and Shudras) and the Indian Muslim community were typed using three STR markers, DXS548, FRAXAC1, and FRAXAC2. Results and Conclusion: A wide range of haplotypes were observed, with 7-3-4+ being modal in Brahmins, Kshatriyas, and Vaishyas. This finding is in keeping with data from other Caucasian populations of European and North American origin. The report is the first of its kind, providing a normative background for meaningful haplotype comparisons between different Indian communities and with the fragile X individuals.