Swarup, Ghanshyam ; Cohen, Stanley ; Garbers, David L. (1982) Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate Biochemical and Biophysical Research Communications, 107 (3). pp. 1104-1109. ISSN 0006-291X
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0006-291X(82)90635-0
Abstract
We have investigated the effect of vanadate on the phosphoserine-and phosphotyrosine-specific phosphoprotein phosphatase activities of A-431 cell membranes and have found that micromolar concentrations of vanadate strongly inhibit the membrane-dependent dephosphorylation of histones containing phosphotyrosine but that they do not inhibit the dephosphorylation of histones containing phosphoserine and phosphothreonine. In addition, the dephosphorylation of endogeneous membrane proteins of A-431 cells (which are known to be phosphorylated at tyrosine residues) was inhibited by vanadate. These results show that vanadate is a potent and selective inhibitor of phosphotyrosyl-protein phosphatase.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | EGF; Epidermal Growth Factor; Phospho-Tyr-histones; Histones Phosphorylated At Tyrosine; Phospho-Ser-histones; Histones Phosphorylated At Serine And Threonine |
| ID Code: | 54447 |
| Deposited On: | 11 Aug 2011 10:48 |
| Last Modified: | 11 Aug 2011 10:48 |
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