Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate

Swarup, Ghanshyam ; Cohen, Stanley ; Garbers, David L. (1982) Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate Biochemical and Biophysical Research Communications, 107 (3). pp. 1104-1109. ISSN 0006-291X

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We have investigated the effect of vanadate on the phosphoserine-and phosphotyrosine-specific phosphoprotein phosphatase activities of A-431 cell membranes and have found that micromolar concentrations of vanadate strongly inhibit the membrane-dependent dephosphorylation of histones containing phosphotyrosine but that they do not inhibit the dephosphorylation of histones containing phosphoserine and phosphothreonine. In addition, the dephosphorylation of endogeneous membrane proteins of A-431 cells (which are known to be phosphorylated at tyrosine residues) was inhibited by vanadate. These results show that vanadate is a potent and selective inhibitor of phosphotyrosyl-protein phosphatase.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:EGF; Epidermal Growth Factor; Phospho-Tyr-histones; Histones Phosphorylated At Tyrosine; Phospho-Ser-histones; Histones Phosphorylated At Serine And Threonine
ID Code:54447
Deposited On:11 Aug 2011 10:48
Last Modified:11 Aug 2011 10:48

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