Ananth, Kumari Murthy ; Rajaram, Rama ; Ramasami, Thirumalachari (2000) Stabilization of chromium(V) species in bovine serum albumin adduct Biochemical and Biophysical Research Communications, 273 (3). pp. 1138-1143. ISSN 0006-291X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1006/bbrc.2000.3069
Abstract
A detailed investigation of molecular interactions of the protein bovine serum albumin (BSA) with potassium dichromate has been made. Compelling evidence for the formation of a relatively stable Cr(V) species which decays only slowly to afford Cr(III) products has been obtained. The resulting final chromium(III) product mediates in cross-linking of BSA. The implications of the formation of a relatively stable chromium(V) as well as chromium(III)-mediated cross-links in the marker protein are discussed in the context of the metal ion-induced biotoxicity.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Stable Cr(V) BSA Adduct; Cross-linking of BSA; Cr(V) Decay; BSA; Chromium; EPR |
| ID Code: | 53349 |
| Deposited On: | 08 Aug 2011 07:47 |
| Last Modified: | 08 Aug 2011 07:47 |
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