Gayatri, Raghuraman ; Sharma, Ashok Kumar ; Rajaram, Rama ; Ramasami, Thirumalachari (2001) Chromium(III)-induced structural changes and self-assembly of collagen Biochemical and Biophysical Research Communications, 283 (1). pp. 229-235. ISSN 0006-291X
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1006/bbrc.2001.4713
Abstract
Rat tail tendon (RTT) collagen has been reacted with a homologous series of chromium(III) complexes viz., (H2O)4Cr(OH)2Cr(H2O)4+4̲1 (dimer), Cr3(OH)4(H2O)5+9̲2 (trimer), and Cr4(OH)4(O)2(H2O)4+12̲ 3(tetramer), and the structural alterations brought about by these complexes have been investigated through atomic force microscopy (AFM) and circular dichroism (CD) studies. Examination of Cr(III)-treated tendons using AFM revealed changes in the D-periodicity of collagen, which may arise due to differences in the topological distribution of various Cr(III) complexes. Evidence for organisation of monomeric collagen into quarter staggered fibrils in the presence of Cr(III) dimer,̲1, has been obtained. The quaternary structural changes induced by chromium in the protein have been correlated to the conformational changes of collagen in the absence of denaturation.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Collagen; Chromium (III) Complexes; Atomic Force Microscope; D-periodicity; Conformation; Aggregation |
| ID Code: | 53335 |
| Deposited On: | 10 Aug 2011 09:54 |
| Last Modified: | 10 Aug 2011 09:54 |
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