Mechanism of meiotic recombination in eukaryotes- a theory

Subrahmanyam, N. C. (1977) Mechanism of meiotic recombination in eukaryotes- a theory Journal of Theoretical Biology, 64 (4). pp. 739-745. ISSN 0022-5193

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It is proposed that in meiotic chromosomes single strand breaks of DNA originate either in the delayed regions of replicons or as a result of the excision activity of DNA polymerase during zygotene DNA synthesis. Rejoining of the break points belonging to non-sister chromatids takes place by switching over of the polymerase from one strand of DNA to another non-sister strand of the same polarity and gives rise to recombination intermediates (half-chromatid chiasmata). Strand migration in a recombination intermediate or copying of the same parental strand twice during zygotene as a consequence of a delay in copying the homologous strand would lead to gene conversion. Nicking of the cross strands (parental strands) in any recombination intermediate and subsequent repair leads to recombination for flanking markers. A possible way in which three-strand double crossovers occur and the process of recombination are discussed.

Item Type:Article
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ID Code:53153
Deposited On:05 Aug 2011 07:22
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