Necrosis and inhibition of growth of human lung tumor by anti-α-human chorionic gonadotropin antibody

Kumar, Sanjeev ; Talwar, G. P. ; Biswas, Debajit K. (1992) Necrosis and inhibition of growth of human lung tumor by anti-α-human chorionic gonadotropin antibody Journal of the National Cancer Institute, 84 (1). pp. 42-47. ISSN 0027-8874

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Official URL: http://jnci.oxfordjournals.org/content/84/1/42.sho...

Related URL: http://dx.doi.org/10.1093/jnci/84.1.42

Abstract

Human lung tumor cells (ChaGo) established in culture from a broncho-genie squamous cell carcinoma synthesize and secrete large amouts of human chorionic gonadotropin (HCG), predominatly the α subunit of the gly-coprotein hormone. ChaGo cells lose their transformation phenotypes following treatment with anti α-HCG antibody or following inhibition of intracellular synthesis of α-HCG by the anti-sense RNA technique. We report that tumors induced by ChaGo cells in female athymic mice undergo necortic degeneration following local of intra peritoneal administration of α-HCG-specific-antibody. The α-HCG antibody did not affect the growth of tumors induced by α-HCG nonproducing human tumor cells. Histopathological examinations of the anti-αHCG antibody-treated tumor tissues showed active necrosis. When the antibody treatment was discontinued, the tumorigenesis process resumed. When anti α-HCG antibody was administered simultaneously with ChaGo cells, a concentration-dependent inhibition of tumor growth in athymic mice was completely prevented at higher concentrations of the specific antibody.

Item Type:Article
Source:Copyright of this article belongs to Oxford University Press.
ID Code:52867
Deposited On:04 Aug 2011 09:50
Last Modified:12 Aug 2011 08:40

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