Mutational specificity of benzo[a]pyrene diolepoxide in monkey cells

Roilides, Emmanuel ; Gieden, Jacques E. ; Tuteja, Narendra ; Levine, Arthur S. ; Dixon, Kathleen (1988) Mutational specificity of benzo[a]pyrene diolepoxide in monkey cells Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis, 198 (1). pp. 199-206. ISSN 1386-1964

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Benzo[a]pyrene diolepoxide (BPDE) is thougth to be the major mutagenic and carcinogenic intermediate in benzo[a]pyrene metabolism in mammalian cells. In order to test the mutagenic specificity of this compound in mammalian cells, we have used the PZ189 shuttle vector system to identify and analyze point mutations induced when DNA treated in vitro with BPDE is replicated in monkey cells. We find that point mutations occur almost exclusively at G·C base pairs; G·C→T·A and G·C→C·G transversions and single base pair deletions occur most frequently. This pattern is consistent with the known preferential covalent binding of BPDE to redisue.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Benzo[a]pyrene Diolepoxide; Mutagenicity; (Mammals)
ID Code:52729
Deposited On:04 Aug 2011 11:54
Last Modified:04 Aug 2011 11:54

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