Nonsteroidal anti-inflammatory drugs inhibit gastric peroxidase activity

Banerjee, Ranajit K (1990) Nonsteroidal anti-inflammatory drugs inhibit gastric peroxidase activity Biochimica et Biophysica Acta: General Subjects, 1034 (3). pp. 275-280. ISSN 0304-4165

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The peroxidase activity of the mitochondrial fraction of rat gastric mucosa was inhibited with various nonsteroidal anti-inflammatory drugs (NSAIDs) in vitro. Indomethacin was found to be more effective than phenylbutazone (PB) or acetylsalicylic acid (ASA). Mouse gastric peroxidase was also very sensitive to indomethacin inhibition. Indomethacin has no significant effect on submaxillary gland peroxidase activity of either of the species studied. Purified rat gastric peroxidase activity was inhibited 75% with 0.15 mM indomethacin showing half-maximal inhibition at 0.04 mM. The inhibition could be withdrawn by increasing the concentration of iodide but not by H2O2. NSAIDs inhibit gastric peroxidase activity more effectively at acid pH (pH 5.2) than at neutral pH. Spectral studies showed a bathochromic shift of the Soret band of the enzyme with indomethacin indicating its interaction at or near the heme part of the enzyme.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Nonsteroidal Anti-inflammatory Drug; Gastric Peroxidase; Enzyme Inhibition
ID Code:5259
Deposited On:18 Oct 2010 07:38
Last Modified:14 May 2011 09:01

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