On X inactivation in XO embryos of mammals

Sharat Chandra, H. (1970) On X inactivation in XO embryos of mammals Genetical Research, 16 (2). pp. 233-234. ISSN 0016-6723

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Official URL: http://journals.cambridge.org/abstract_S0016672300...

Related URL: http://dx.doi.org/10.1017/S0016672300002469


By analogy with the situation in coccids it is suggested that in mammalian XO embryos the single X turns heterochromatic in some cells, but that such a change does not result in cell death because the X then reverts back to an euchromatic and active state. This testable alternative to the Gartler-Sparkes hypothesis would imply that the anomalies of the XO Turner syndrome are largely due to imbalance of sex-linked genes rather than developmental damage resulting from cell death and that mammalian X inactivation might become reversed in response to special developmental needs.

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