Synthesis of (L) α-2,4-Dinitrophenylhistidne

Ramachandran, L. K. ; Mcconnell, W. B. (1955) Synthesis of (L) α-2,4-Dinitrophenylhistidne Nature, 176 . pp. 931-932. ISSN 0028-0836

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The reaction of histidine with 1 : 2 : 4-fluorodinitrobenzene (FDNB) could yield a di-substituted histidine and two mono-substituted histidines. Di-dinitrophenylhistidine has been prepared in pure form, and although the isolation of a mono-dinitrophenylhistidine has been claimed, neither physical constants nor proof of structure were given. Later workers have not been able to prepare either of the mono-substituted compounds in pure form. Efforts to synthesize -dinitrophenylhistidine were recently reported to have resulted in mixtures containing equal amounts of imidazole dinitrophenylhistidine and α-dinitrophenylhistidine.

Item Type:Article
Source:Copyright of this article belongs to Nature Publishing Group.
ID Code:52357
Deposited On:03 Aug 2011 14:19
Last Modified:03 Aug 2011 14:19

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