Cardiotoxin of the Indian cobra (Naja naja) is a pyrophosphatase

Achyuthan, K. E. ; Ramachandran, L. K. (1981) Cardiotoxin of the Indian cobra (Naja naja) is a pyrophosphatase Journal of Biosciences, 3 (2). pp. 149-156. ISSN 0250-5991

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An inorganic pyrophosphatase has been purified to apparent homogeniety from Indian cobra(Naja naja) venom, with a ten-fold increase in specific activity. The enzyme activity is intrinsic to a protein fraction in the venom which is normally termed cardiotoxin, cobramine, cytotoxin and so on. The enzyme shows a low Km (70 μ M) and high heat stability. The enzyme was active against sodium pyrophosphate; it also hydrolyses a few mononucletides and sugar phosphates at much lower rates. The physiological significance of inorganic pyrophosphatase in venom is discussed.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Cobra Venom; Naja naja; Cardiotoxin; Pyrophosphatase
ID Code:52354
Deposited On:03 Aug 2011 14:22
Last Modified:18 May 2016 05:56

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