Saxena, Rajiv K. (1987) A spleen cell derived factor imparts resistance to NK cell mediated lysis in a mouse lymphoma cell line Immunology Letters, 15 (2). pp. 105-108. ISSN 0165-2478
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0165-2478(87)90039-3
Abstract
The effect of interleukin-2 (IL-2) preparations on the susceptibility of YAC cells to mouse natural killer (NK) cells was examined. Crude IL-2 preparations induced a significant decrease in the susceptibility of YAC cells. Highly purified IL-2 preparations, however, did not have a similar effect. Since the IL-2 preparations used in this study were purified from the culture supernatant of Con A activated spleen cells (Con A Sup.), our results indicated the presence in Con A Sup. of a lysis resistance inducing factor (LRIF), distinct from IL-2. We were able to purify LRIF from Con A Sup. by preparative isoelectric focusing and determined its isoelectric pH to be 4.8.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | NK Cell; Lysis Resistance; Interleukin-2; Interferon; Mouse Lymphoma |
| ID Code: | 51765 |
| Deposited On: | 30 Jul 2011 05:36 |
| Last Modified: | 30 Jul 2011 05:36 |
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