Neuronal Ca2+ signaling via caldendrin and calneurons

Mikhaylova, Marina ; Sharma, Yogendra ; Reissner, Carsten ; Nagel, Falko ; Aravind, Penmatsa ; Rajini, Bheemreddy ; Smalla, Karl-Heinz ; Gundelfinger, Eckart D. ; Kreutz, Michael R. (2006) Neuronal Ca2+ signaling via caldendrin and calneurons Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1763 (11). pp. 1229-1237. ISSN 0167-4889

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.bbamcr.2006.08.047

Abstract

The calcium sensor protein caldendrin is abundantly expressed in neurons and is thought to play an important role in different aspects of synapto-dendritic Ca2+ signaling. Caldendrin is highly abundant in the postsynaptic density of a subset of excitatory synapses in brain and its distinct localization raises several decisive questions about its function. Previous work suggests that caldendrin is tightly associated with Ca2+- and Ca2+ release channels and might be involved in different aspects of the organization of the postsynaptic scaffold as well as with synapse-to-nucleus communication. In this report we introduce two new EF-hand calcium sensor proteins termed calneurons that apart from calmodulin represent the closest homologues of caldendrin in brain. Calneurons have a different EF-hand organization than other calcium sensor proteins, are prominently expressed in neurons and will presumably bind Ca2+ with higher affinity than caldendrin. Despite some significant structural differences it is conceivable that they are involved in similar Ca2+ regulated processes like caldendrin and neuronal calcium sensor proteins.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:EF-hand Ca2+ Signaling; Caldendrin; Calmodulin; Calneurons; Ca2+ Binding Affinities; CaBP1; Structural Modeling
ID Code:50868
Deposited On:27 Jul 2011 13:27
Last Modified:27 Jul 2011 13:27

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