Mechanism of phagocytosis by Schwann cell

Band, Hamid ; Bhattacharya, Alok ; Talwar, Gursaran P. (1986) Mechanism of phagocytosis by Schwann cell Journal of the Neurological Sciences, 75 (1). pp. 113-119. ISSN 0022-510X

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33B rat Schwannoma cell line is known to exhibit phagocytic properties analogous to those of normal Schwann cells. The mechanism of phagocytosis by this cell line was investigated by studying the effect of known modulators of phagocytosis on the uptake of latex particles by these cells. Treatments which block energy production of the host cell, such as incubation at 4°C and treatment with sodium azide, markedly inhibited the phagocytosis of latex particles by these cells. Phagocytosis was dose-dependently, and completely, inhibited by cytochalasin B, demonstrating an important role of microfilaments. Colchicine produced a minor inhibition of phagocytosis only at the highest concentration (10−3 M) tested, suggesting that intact microtubules are not crucial for latex phagocytosis. Dibutyryl cyclic AMP was without any effect on the phagocytosis. Thus, latex phagocytosis by rat Schwannoma cells is an active, energy-dependent process requiring intact microfilaments with only a minor dependence on microtubules.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Colchicine; Cyclic AMP; Cytochalasin; Microfilaments; Microtubules; Phagocytosis; Schwann Cell
ID Code:50676
Deposited On:26 Jul 2011 08:09
Last Modified:10 Aug 2011 06:00

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