Raghuvanshi, Rajeev Singh ; Singh, Manmohan ; Talwar, G. P. (1993) Biodegradable delivery system for single step immunization with tetanus toxoid International Journal of Pharmaceutics, 93 (1-3). R1-R5. ISSN 0378-5173
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0378-5173(93)90188-L
Abstract
Tetanus toxoid (TT) loaded biodegradable microspheres were prepared from poly(dl-lactide-co-glycolide) (monomer ratio 65:35) of Mol. Wt 75 000. The method of preparation was emulsification-solvent evaporation. In vitro vaccine release data are discussed. An in vivo immune response study was performed on rats. Results of immunization with the conventional schedule of TT and encapsulated TT until 5 months after immunization are presented, which were found to be comparable.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Biodegradable Polymer; Poly(DL-lactide-co-glycolide); Tetanus Toxoid; Vaccine; Controlled Delivery; Neonatal Tetanus |
| ID Code: | 50652 |
| Deposited On: | 26 Jul 2011 13:03 |
| Last Modified: | 26 Jul 2011 13:03 |
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