Expression of NEU/HER-2 oncoprotein (p185neu) in prostate tumors: an immunohistochemical study

Giri, Dipak K. ; Wadhwa, Surender N. ; Upadhaya, Sakti N. ; Talwar, Gursaran P. (1993) Expression of NEU/HER-2 oncoprotein (p185neu) in prostate tumors: an immunohistochemical study The Prostate, 23 (4). pp. 329-336. ISSN 0270-4137

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Official URL: http://onlinelibrary.wiley.com/doi/10.1002/pros.29...

Related URL: http://dx.doi.org/10.1002/pros.2990230406

Abstract

The expression of the neu oncogene product was investigated immunohistochemically in 36 cases of benign prostatic hyperplasia (BPH) and seven cases of adenocarcinoma of prostate (CaP). c-neu oncogene encodes a transmembrane growth factor receptor that has partial structural homology with EGF receptor, and is overexpressed and amplified in a number of human tumors, specially, breast cancers. Using a monoclonal antibody, AB-3, which recognizes -COOH-terminal of neu oncoprotein, we have analyzed immunohistochemically the expression of this protein in buffered formalin and Zamboni fluid-fixed surgically removed tissues. Focal patchy and/or diffused cytoplasmic staining of varying intensity was observed in 34 of 36 BPH cases. Four cases showed cell membrane staining as well (4/36=11%). All seven cases of adenocarcinomas had moderate to strong c-neu immunoreactivity, and two gave a distinct cell membrane-positive reaction (100%). The available data indicate that prostatic tumors as well as a high percentage of prostatic hyperplasia tissues express c-neu protein; however, its role in cellular proliferation needs further study.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:c-neu; HER-2; erbB-2; Oncogene; Prostate Tumors; Immunohistochemistry
ID Code:50521
Deposited On:26 Jul 2011 08:19
Last Modified:26 Jul 2011 08:19

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