Francis, A. K. ; Rao, Ch. Pulla ; Iqbal, M. ; Nagaraj, R. ; Vijayan, M. ; Balaram, P. (1982) Helical conformations of three crystalline pentapeptide fragments of suzukacillin, a membrane channel forming polypeptide Biochemical and Biophysical Research Communications, 106 (4). pp. 1240-1247. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-291X(82)91245-1
Abstract
The crystal structures of three pentapeptide fragments of suzukacillin-A have been determined. Boc-Aib-Pro-Val-Aib-Val-OMe (peptide 1-5) adopts a distorted helical conformation, stabilized by three intramolecular hydrogen bonds (two 5→1, one 4→1). Boc-Ala-Aib-Ala-Aib-Aib-OMe (peptide 6-10) and Boc-Leu-Aib-Pro-Val-Aib-OMe (peptide 16-20) adopt 310 helical structures stabilized by three and two 4→1 intramolecular hydrogen bonds, respectively. These structures provide substantial support for a largely helical conformation for the suzukacillin membrane channel.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
ID Code: | 5020 |
Deposited On: | 18 Oct 2010 05:30 |
Last Modified: | 16 May 2011 08:58 |
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