Helical conformations of three crystalline pentapeptide fragments of suzukacillin, a membrane channel forming polypeptide

Francis, A. K. ; Rao, Ch. Pulla ; Iqbal, M. ; Nagaraj, R. ; Vijayan, M. ; Balaram, P. (1982) Helical conformations of three crystalline pentapeptide fragments of suzukacillin, a membrane channel forming polypeptide Biochemical and Biophysical Research Communications, 106 (4). pp. 1240-1247. ISSN 0006-291X

Full text not available from this repository.

Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...

Related URL: http://dx.doi.org/10.1016/0006-291X(82)91245-1

Abstract

The crystal structures of three pentapeptide fragments of suzukacillin-A have been determined. Boc-Aib-Pro-Val-Aib-Val-OMe (peptide 1-5) adopts a distorted helical conformation, stabilized by three intramolecular hydrogen bonds (two 5→1, one 4→1). Boc-Ala-Aib-Ala-Aib-Aib-OMe (peptide 6-10) and Boc-Leu-Aib-Pro-Val-Aib-OMe (peptide 16-20) adopt 310 helical structures stabilized by three and two 4→1 intramolecular hydrogen bonds, respectively. These structures provide substantial support for a largely helical conformation for the suzukacillin membrane channel.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:5020
Deposited On:18 Oct 2010 05:30
Last Modified:16 May 2011 08:58

Repository Staff Only: item control page