Howard, F. B. ; Todd Miles, H. ; Liu, Keliang ; Frazier, J. ; Raghunathan, G. ; Sasisekharan, V. (1992) Structure of d(T)n·d(A)n·d(T)n: the DNA triple helix has B-form geometry with C2'-endo sugar pucker Biochemistry, 31 (44). pp. 10671-10677. ISSN 0006-2960
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Official URL: http://pubs.acs.org/doi/abs/10.1021/bi00159a005
Related URL: http://dx.doi.org/10.1021/bi00159a005
Abstract
The polynucleotide helix d(T)n.d(A)n.d(T)n is the only deoxypolynucleotide triple helix for which a structure has been published, and it is generally assumed as the structural basis for studies of DNA triplexes. The helix has been assigned to an A-form conformation with C3'-endo sugar pucker by Arnott and Selsing. We show here by infrared spectroscopy in D2O solution that the helix is instead B-form and that the sugar pucker is in the C2'-endo region.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to American Chemical Society. |
| ID Code: | 49554 |
| Deposited On: | 21 Jul 2011 10:35 |
| Last Modified: | 21 Jul 2011 10:35 |
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