Sharma, R. P. (1966) Chromosome breakage and enhancement in radiation sensitivity induced by 5-trifluoromethyl-2-deoxy-uridine in Vicia faba Proceedings of the Indian Academy of Sciences, Section B, 64 (1). pp. 22-25. ISSN 0370-0097
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Official URL: http://www.ias.ac.in/j_archive/procb/64/vol64conte...
Related URL: http://dx.doi.org/10.1007/BF03052397
Abstract
The effect of 5-trifluoromethyl-2-deoxyuridine (F3TdR) on the frequency of X-ray-induced chromosomal aberrations has been discussed. F3TdR is a potent chromosome-breaking agent and its chromosome-breaking ability is concentration-dependent. F3TdR sensitizes the system to radiation and increases the frequency of X-ray-induced chromosomal aberration. The radio-sensitization is also concentration dependent. The occurrence of a large number of gaps in both chromatids and chromosomes in chemical-cum-radiation combination treatment supports the idea that the sensitization to radiation results from halogenation following the incorporation of F3TdR in DNA.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Indian Academy of Sciences. |
| ID Code: | 49376 |
| Deposited On: | 20 Jul 2011 05:54 |
| Last Modified: | 20 Jul 2011 05:54 |
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