Activated mouse T cells downregulate, process and present their surface TCR to cognate anti-idiotypic CD4+ T cells

Lal, Girdhari ; Shaila, Melkote S. ; Nayak, Rabindranath (2006) Activated mouse T cells downregulate, process and present their surface TCR to cognate anti-idiotypic CD4+ T cells Immunology and Cell Biology, 84 . pp. 145-153. ISSN 0818-9641

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Official URL: http://www.nature.com/icb/journal/v84/n2/abs/icb20...

Related URL: http://dx.doi.org/10.1111/j.1440-1711.2005.01405.x

Abstract

The ability of activated T cells to present foreign antigens through the MHC class II pathway has been shown in the case of human, rat and mouse T cells. In the present study, the ability of activated T cells to present their endogenous TCR in association with MHC class II molecules to CD4+ T cells was shown. Upon activation mouse T cells downregulate their surface TCR, which are degraded into peptides in endosomal/lysosomal compartments. The idiopeptides (peptides derived from the variable region of the TCR) are presented to cognate anti-idiotypic CD4+ T cells, resulting in activation and proliferation of these cells. Interaction of idiotypic and anti-idiotypic T cells brought about by presentation of TCR idiopeptide may have important implications for T-cell vaccination and perpetuation of T-cell memory not requiring persisting antigen or long-lived memory cells.

Item Type:Article
Source:Copyright of this article belongs to Nature Publishing Group.
Keywords:Antigen Presentation; Anti-idiotypic T Cell; T-cell Memory; T-cell Receptor(TCR)
ID Code:49350
Deposited On:20 Jul 2011 06:19
Last Modified:18 May 2016 04:06

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