Ghosh, Arundhati ; Nayak, Rabindranath ; Shaila, M. S. (1996) Inhibition of replication of rinderpest virus by 5-fluorouracil Antiviral Research, 31 (1-2). pp. 35-44. ISSN 0166-3542
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Official URL: http://www.sciencedirect.com/science/article/pii/0...
Related URL: http://dx.doi.org/10.1016/0166-3542(96)00943-6
Abstract
5-Fluorouracil (5FU), an analogue of uracil, was found to inhibit the production of infectious particles of rinderpest virus (RPV) in Vero cells (African green monkey kidney cells) by 99%, at a concentration of 1 μg/ml. The levels of individual mRNA specific for five of the virus genes were also reduced drastically, while the level of mRNA for a cellular housekeeping gene-glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-was unaltered by fluorouracil treatment of infected cells. Both virus RNA and protein synthesis showed inhibition in a dose-dependent manner. The virions which budded out of 5-fluorouracil-treated cells also contained reduced amounts of virus proteins compared with virus particles from untreated cells.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Rinderpest Virus; 5-Fluorouracil; Virus Transcription; Antiviral Drug |
| ID Code: | 49318 |
| Deposited On: | 20 Jul 2011 06:11 |
| Last Modified: | 20 Jul 2011 06:11 |
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