Perpetuation of immunological memory through common MHC-I binding modes of peptidomimic and antigenic peptides

Gangadhar, Vidya ; Jeyakani, Justin J. ; Shaila, M. S. ; Nayak, Rabindranath ; Chandra, Nagasuma (2007) Perpetuation of immunological memory through common MHC-I binding modes of peptidomimic and antigenic peptides Biochemical and Biophysical Research Communications, 364 (2). pp. 308-312. ISSN 0006-291X

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.bbrc.2007.10.005

Abstract

Understanding the molecular mechanisms of immunological memory assumes importance in vaccine design. We had earlier hypothesized a mechanism for the maintenance of immunological memory through the operation of a network of idiotypic and anti-idiotypic antibodies (Ab2). Peptides derived from an internal image carrying anti-idiotypic antibody are hypothesized to facilitate the perpetuation of antigen specific T cell memory through similarity in peptide-MHC binding as that of the antigenic peptide. In the present work, the existence of such peptidomimics of the antigen in the Ab2 variable region and their similarity of MHC-I binding was examined by bioinformatics approaches. The analysis employing three known viral antigens and one tumor-associated antigen shows that peptidomimics from Ab2 variable regions have structurally similar MHC-I binding patterns as compared to antigenic peptides, indicating a structural basis for memory perpetuation.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Antigen Mimicry; Peptidomimics; MHC-I Binding; Immunological Memory
ID Code:49302
Deposited On:19 Jul 2011 14:02
Last Modified:19 Jul 2011 14:02

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