Recombinant idiotypic TCRβ chain immunization in mice generates antigen specific T cell response

Lal, Girdhari ; Shaila, M. S. ; Nayak, Rabindranath (2006) Recombinant idiotypic TCRβ chain immunization in mice generates antigen specific T cell response Molecular Immunology, 43 (10). pp. 1549-1556. ISSN 0161-5890

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.molimm.2005.10.002

Abstract

Vaccination remains the most cost-effective means of preventing infectious diseases. Success of vaccination depends on generation of effective memory response. Understanding the mechanism of generation and maintenance of immunological memory would help in the design of rational vaccines. T lymphocytes play a central role in the generation of protective immune response against many microbial infections. A hypothesis known as relay hypothesis was earlier proposed, which explains the maintenance of immunological memory through interaction of idiotypic and anti-idiotypic lymphocytes. In the present study, we have shown that immunization with a model antigen, chicken ovalbumin specific T cell receptor beta chain (idiotypic TCR) generates TCR specific antibody and anti-idiotypic T cell responses as well as ovalbumin specific T cell response. We further show that boosting of ovalbumin primed mice with ovalbumin specific idiotypic TCRβ DNA or TCRβ protein gives memory response for ovalbumin. This study provides experimental evidence for perpetuation of immunological memory through idiotypic network interactions.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Anti-idiotypic T Cells; DNA Vaccine; T Cell Receptor; T Cell Memory; Relay Hypothesis
ID Code:49284
Deposited On:19 Jul 2011 14:00
Last Modified:19 Jul 2011 14:00

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