The crafting of uracils with enhanced stacking potential

Ranganathan, Subramania ; Kundu, Dinabandhu ; Mehrotra, Sanjiv (1994) The crafting of uracils with enhanced stacking potential Journal of Chemical Sciences, 106 (5). pp. 1051-1070. ISSN 0253-4134

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Uracils having enhanced stacking profile are of interest from diverse vantages ranging from the chemical simulation of transcription to the design of novel anti viral agents. This objective has been realized by synthetic strategies leading to uracils having,inter alia, pseudo aromatic and hydrophobic rings crafted to the 5-6 location and ionophore and hydrophobic chains affixed at the C-5 and nitrogen atoms. Endeavours to prepare a 5-2' uracil-pyrimidine composite have led to novel uracil arising from 2-O → =CH(COOR)2 transformation and a tethered malonic acid pyrimidine complex.

Item Type:Article
Source:Copyright of this article belongs to Indian Academy of Sciences.
Keywords:Attenuation; Uracil; Non-Covalent Interactions; Stacking Profile
ID Code:48872
Deposited On:20 Jul 2011 06:50
Last Modified:18 May 2016 03:49

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