The synthesis of PGF1α by re-structuring of castor oil

Ranganathan, D. ; Ranganathan, S. ; Mehrotra, M. M. (1980) The synthesis of PGF1α by re-structuring of castor oil Tetrahedron, 36 (12). pp. 1869-1875. ISSN 0040-4020

Full text not available from this repository.

Official URL:

Related URL:


Castor oil has been transformed-via methyl ricinoleate-to PGF1α by strategy wherein 16 of the 18 carbons of the castor oil backbone are incorporated in the C-20 PGF1α, involving, inter alia, a novel procedure for the regiospecific functionalisation of terminal olefins, a novel degradation of aldehyde to lower acid and strategies useful for the generation of the highly functionalised prostanoid system, which specially illustrate the utility of MEM protecting group in diverse types of chemical transformations. Additionally, this work describes the preparation of synthons having potential utility and the synthesis of novel homo-PGP1α.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:48847
Deposited On:20 Jul 2011 06:40
Last Modified:01 Jul 2012 07:17

Repository Staff Only: item control page