Radical cyclizations in the synthesis of natural products

Abstract

Organic chemists have began to use intramolecular radical addition reactions i.e. radical cyclization to develop useful synthetic transformations. The mild reactions conditions and the observed selectivities made these radical cyclizaiona a viable alternative to the conventional polar reactions. Applicatin of polar radical cyclization strategy to various natural products like sesquiterpenes (sativenes, agarofuransm, hirsutene, capnellenes, silphiperfolene, seychellene, patchoulli alcohol), marine deterpene isoamijiol, pyrrolizidine alkaloids. (dehydrohastanecine, heliotridine, hastanecine), by various organic chemists demonstrates the versatility of this relatively new area in organic synthesis.