A fluorescent probe study of the solubilisation of cholesterol by bile salt-phospholipid micelles

Paul, Ranajit ; Balaram, P. (1978) A fluorescent probe study of the solubilisation of cholesterol by bile salt-phospholipid micelles Biochemical and Biophysical Research Communications, 81 (3). pp. 850-857. ISSN 0006-291X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...

Related URL: http://dx.doi.org/10.1016/0006-291X(78)91429-8

Abstract

The fluorescent probe dansyl cadaverine has been shown to bind strongly to mixed bile salt-phospholipid micelles containing unsaturation in the fatty acyl chains. Incorporation of cholesterol into the mixed micelles reduces the number of molecules of bound dansyl cadaverine without altering the binding affinity. These results suggest a tighter packing of the hydrocarbon matrix of the micelles in the presence of cholesterol.

Item Type:Article
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ID Code:4880
Deposited On:18 Oct 2010 06:21
Last Modified:16 May 2011 09:31

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