Synthesis and studies of Cu(II)-thiolato complexes: bioinorganic perspectives

Mandal, Subrata ; Das, Gopal ; Singh, Ramsharan ; Shukla, Rameshwer ; Bharadwaj, Parimal K. (1997) Synthesis and studies of Cu(II)-thiolato complexes: bioinorganic perspectives Coordination Chemistry Reviews, 160 . pp. 191-235. ISSN 0010-8545

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Ligation of thiolate sulfur to copper at the active sites of quite a number of copper proteins has been established either by X-ray crystallographic and/or by spectroscopic studies. In addition, for Cu(II)-substituted metalloproteins, the presence of Cu(II)-thiolate bonding at the active sites could be established spectroscopically. Cu(II)-thiolate bonding in different enzymes is not always very similar. Obviously, the bioinorganic significance of Cu(II)-thiolate bonding is enormous and has attracted a lot of attention to synthesize model Cu(II)-thiolato complexes as electronic structural analogues of the active sites of these biomolecules. The present review deals with (i) nature of Cu(II)-thiolate bonding present in different metalloproteins, (ii) difficulties involved in the synthesis of Cu(II)-thiolates and ways to surmount them, (iii) characterization of the Cu(II)-thiolate bonding by electronic and EPR spectroscopic techniques and (iv) electron transfer properties of the Cu(II)-thiolato complexes by cyclic voltammetric studies. The properties of the Cu(II)-thiolato complexes have been discussed as possible models for the active site(s) of copper proteins.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Synthesis; Cu(II)-thiolato Complexes
ID Code:4843
Deposited On:18 Oct 2010 06:32
Last Modified:18 May 2011 09:18

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