Reversal of handedness in DNA: a stable link between RU and LZ helices

Gupta, Goutam ; Bansal, Manju ; Sasisekharan, V. (1980) Reversal of handedness in DNA: a stable link between RU and LZ helices Biochemical and Biophysical Research Communications, 97 (4). pp. 1258-1267. ISSN 0006-291X

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00062...

Related URL: http://dx.doi.org/10.1016/S0006-291X(80)80002-7

Abstract

Two types of left-handed zig-zag (LZ) helices were obtained following stereochemical guideline. They are referred to as LZ1 and LZ2 helices. LZ1 helices have conformations similar to those found in the single crystals of d(C-G)3 and d(C-G)2. Z-character is more prominent in LZ2 than in LZ1 helix. The conformations of a stable link between RU and LZ helical fragments are given. The link involves inverted stacking arrangement of the bases: a characteristic feature of all RL models proposed by us.

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