Novel peptides of therapeutic promise from Indian conidae

Gowd, K. Hanumae ; Sabareesh, V. ; Sudarslal, S. ; Iengar, Prathima ; Franklin, Benjamin ; Fernando, Antony ; Dewan, Kalyan ; Ramaswami, Mani ; Sarma, Siddhartha P. ; Sikdar, Sujit ; Balaram, P. ; Krishnan, K. S. (2005) Novel peptides of therapeutic promise from Indian conidae Annals of the New York Academy of Sciences, 1056 . pp. 462-473. ISSN 0077-8923

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Highly structured small peptides are the major toxic constituents of the venom of cone snails, a family of widely distributed predatory marine molluscs. These animals use the venom for rapid prey immobilization. The peptide components in the venom target a wide variety of membrane-bound ion channels and receptors. Many have been found to be highly selective for a diverse range of mammalian ion channels and receptors associated with pain-signaling pathways. Their small size, structural stability, and target specificity make them attractive pharmacologic agents. A select number of laboratories mainly from the United States, Europe, Australia, Israel, and China have been engaged in intense drug discovery programs based on peptides from a few snail species. Coastal India has an estimated 20-30% of the known cone species; however, few serious studies have been reported so far. We have begun a comprehensive program for the identification and characterization of peptides from cone snails found in Indian Coastal waters. This presentation reviews our progress over the last 2 years. As expected from the evolutionary history of these venom components, our search has yielded novel peptides of therapeutic promise from the new species that we have studied.

Item Type:Article
Source:Copyright of this article belongs to New York Academy of Sciences.
Keywords:Novel Peptides; Conidae; Molluscs; Contryphans
ID Code:4741
Deposited On:18 Oct 2010 06:54
Last Modified:16 May 2016 15:21

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