Antilymphoproliferative activity of ethanolic extract of Boerhaavia diffusa roots

Mehrotra, S. ; Singh, V. K. ; Agarwal, S. S. ; Maurya, R. ; Srimal, R. C. (2002) Antilymphoproliferative activity of ethanolic extract of Boerhaavia diffusa roots Experimental and Molecular Pathology, 72 (3). pp. 236-242. ISSN 0014-4800

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Extracts of plants have been widely evaluated for possible antiproliferative and anticarcinogenic properties. The antiproliferative activity of ethanolic extract of Boerhaavia diffusa, a plant used in traditional medicine, was evaluated in several cells. It inhibited T cell mitogen phytohemagglutinin and concanavalin A-stimulated proliferation of human peripheral blood mononuclear cells (PBMC). It also inhibited purified protein derivative antigen-stimulated PBMC proliferation and human mixed lymphocyte culture. In addition, B. diffusa extract inhibited the growth of several cell lines of mouse and human origin, such as mouse macrophage cells (RAW 264.7), human macrophage cells (U937), human monocytic cells (THP-1), mouse fibroblast cells (L929), human embryonic kidney cells (HEK293), mouse liver cells (BNLCL.2), African green monkey kidney cells (COS-1), mouse lymphoma cells (EL-4), human erythroleukemic cells (K562), and human T cells (Jurkat). The present study has demonstrated the antiproliferative potential of ethanolic extract of B. diffusa in vitro.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Boerhaavia diffusa; Concanavalin A; Lymphocyte Proliferation; Mixed Lymphocyte Reaction; Phytohemagglutinin; Purified Protein Derivative
ID Code:47
Deposited On:16 Sep 2010 10:54
Last Modified:11 May 2011 07:47

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