Prevalence of chromosome defects in azoospermic and oligoastheno-teratozoospermic South Indian infertile men attending an infertility clinic

Lakshmi Rao, K. ; Arvind Babu, K. ; Kanakavalli, M. K. ; Padmalatha, V. V. ; Deenadayal, Mamata ; Singh, Lalji (2005) Prevalence of chromosome defects in azoospermic and oligoastheno-teratozoospermic South Indian infertile men attending an infertility clinic Reproductive BioMedicine Online, 10 (4). pp. 467-472. ISSN 1472-6483

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Official URL: http://www.rbmojournal.com/article/S1472-6483%2810...

Related URL: http://dx.doi.org/10.1016/S1472-6483(10)60822-X

Abstract

The prevalence of chromosomal abnormalities in azoospermic and oligoastheno-teratozoospermic infertile men of South Indian origin undergoing assisted reproductive technologies was evaluated. In addition, the study aimed to investigate new abnormal karyotypes involving autosomes in azoospermia and sex chromosomes in oligoastheno-teratozoospermic individuals that are supposed to be rare. Metaphase chromosomes of 744 infertile men, including 272 men with azoospermia and 472 men with oligoastheno-teratozoospermia (OAT), were analysed using Giemsa-trypsin-Giemsa banding and fluorescence in-situ hybridization (FISH) wherever necessary. Chromosomal abnormalities were observed in 59 (7.9%) individuals of the total studied population. Among these, 30 out of 272 (11.0%) azoospermic men and 29 out of 472 (6.1%) infertile men with OAT showed chromosomal abnormalities. A strong and statistically significant association (OR=1.89; P=0.0235) of chromosomal abnormalities and sex chromosome abnormalities (OR=4.29; P=0.001) with azoospermia when compared with OAT was observed. In addition, six autosomal abnormalities associated with azoospermia and two abnormalities involving Y chromosome, which include a novel karyotype (mos 46, XY/51, XYYYYYY) in OAT individuals, were detected.

Item Type:Article
Source:Copyright of this article belongs to Reproductive BioMedicine Online.
Keywords:Azoospermia; Chromosome Abnormalities; ICSI; Karyotype; Male Infertility; Oligoastheno-teratozoospermia
ID Code:46854
Deposited On:06 Jul 2011 06:42
Last Modified:06 Jul 2011 06:42

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