Govindaraj, Periyasamy ; Khan, Nahid Akhtar ; Gopalakrishna, Praturi ; Chandra, Rampalli Viswa ; Vanniarajan, Ayyasamy ; Reddy, Aileni Amarendra ; Singh, Shashi ; Kumaresan, Rathinam ; Srinivas, Gunda ; Singh, Lalji ; Thangaraj, Kumarasamy (2011) Mitochondrial dysfunction and genetic heterogeneity in chronic periodontitis Mitochondrion, 11 (3). pp. 504-512. ISSN 1567-7249
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Official URL: http://www.sciencedirect.com/science/article/pii/S...
Related URL: http://dx.doi.org/10.1016/j.mito.2011.01.009
Abstract
We performed an extensive study on mitochondrial dysfunction in chronic periodontitis (CP). Electron microscopic analysis of gingival cells revealed abnormal mitochondria in 60% of the patients. Mitochondrial membrane potential and oxygen consumption of gingival cells were reduced by 4 fold and 5.8 fold, respectively; whereas ROS production was increased by 18%. The genetic analysis by complete mitochondrial DNA sequencing revealed the identification of 14 novel mutations only in periodontal tissues but not in the blood, suggesting a role of oxidative stress on periodontal tissues. Thus, our functional and genetic analysis provided an evidence for the mitochondrial dysfunction in CP.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Elsevier Science. |
| Keywords: | Chronic Periodontitis; Mitochondria; mtDNA; Mutations; ROS |
| ID Code: | 46832 |
| Deposited On: | 06 Jul 2011 06:58 |
| Last Modified: | 06 Jul 2011 06:58 |
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