The conserved nucleotide sequences of Bkm, which define Sxr in the mouse, are transcribed

Singh, Lalji ; Phillips, Crispin ; Jones, Kenneth W. (1984) The conserved nucleotide sequences of Bkm, which define Sxr in the mouse, are transcribed Cell, 36 (1). pp. 111-120. ISSN 0092-8674

Full text not available from this repository.

Official URL: http://www.cell.com/retrieve/pii/0092867484900795

Related URL: http://dx.doi.org/10.1016/0092-8674(84)90079-5

Abstract

We have recovered a conserved transcribed component of the snake W chromosome satellite DNA (Bkm) from Drosophila and male mouse libraries. This consists of repeats of the tetranucleotide GATA that are concentrated in the sex-determining region of the Y chromosome of mouse, on the W chromosome of snakes, and in the proximal region of the X chromosome of D. melanogaster, and it appears to be transcribed in a sex-specific and developmentally regulated manner. Sequencing studies show that, unlike most other transcribed repeats, the GATA repeats potentially contain open reading frames. These encode mainly the amino acids leucine, serine, isoleucine, and tyrosine but with occasional variant codons that differ in different clonal isolates. Transcription is exclusive to the GATA strand in different tissues of the same organism and in different unrelated organisms. The complementary strand CTAT contains stop codons in all reading frames. The possible developmental significance of these sequences is discussed.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:46800
Deposited On:06 Jul 2011 05:02
Last Modified:06 Jul 2011 05:02

Repository Staff Only: item control page