Anti-malarial activity of some xanthones isolated from the roots of Andrographis paniculata

Dua, V. K. ; Ojha, V. P. ; Roy, R. ; Joshi, B. C. ; Valecha, N. ; Usha Devi, C. ; Bhatnagar, M. C. ; Sharma, V. P. ; Subbarao, S. K. (2004) Anti-malarial activity of some xanthones isolated from the roots of Andrographis paniculata Journal of Ethnopharmacology, 95 (2-3). pp. 247-251. ISSN 0378-8741

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Official URL: http://www.sciencedirect.com/science/article/pii/S...

Related URL: http://dx.doi.org/10.1016/j.jep.2004.07.008

Abstract

Four xanthones were isolated from the roots of Andrographis paniculata using a combination of column and thin-layer chromatographic methods. They were characterized as (i) 1,8-di-hydroxy-3,7-dimethoxy-xanthone, (ii) 4,8-dihydroxy-2,7-dimethoxy-xanthone, (iii)1,2-dihydroxy-6,8-dimethoxy-xanthone and (iv) 3,7,8-trimethoxy-1-hydroxy xanthone by IR, MS and NMR spectroscopic methods. In vitro study revealed that compound 1,2-dihydroxy-6,8-dimethoxy-xanthone possessed substantial anti-plasmodial activity against Plasmodium falciparum with its IC50 value of 4 μg ml−1. Xanthones bearing hydroxyl group at 2 position demonstrated most potent activity while xanthones with hydroxyl group at 1,4 or 8 position possessed very low activity. In vivo anti-malarial sensitivity test of this compound on Swiss Albino mice with Plasmodium berghei infection using Peters' 4-0day test gave substantial reduction (62%) in parasitaemia after treating the mice with 30 mg kg−1 dose. In vitro cytotoxicity against mammalian cells revealed that 1,2-dihydroxy-6,8-dimethoxy-xanthone is non-cytotoxic with its IC50 > 32 μg ml−1.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Andrographis paniculata; Xanthones; Plasmodium falciparum; Plasmodium berghei; Anti-malarial Activity
ID Code:46582
Deposited On:05 Jul 2011 11:50
Last Modified:05 Jul 2011 11:50

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