C-H...O hydrogen bond mediated chain reversal in a peptide containing a γ-amino acid residue, determined directly from powder X-ray diffraction data

Cheung, Eugene Y. ; McCabe, Emma E. ; Harris, Kenneth D. M. ; Johnston, Roy L. ; Tedesco, Emilio ; Raja, K. Muruga Poopathi ; Balaram, Padmanabhan (2002) C-H...O hydrogen bond mediated chain reversal in a peptide containing a γ-amino acid residue, determined directly from powder X-ray diffraction data Angewandte Chemie International Edition, 41 (3). pp. 494-496. ISSN 1433-7851

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Official URL: http://www3.interscience.wiley.com/journal/9001077...

Related URL: http://dx.doi.org/10.1002/1521-3773(20020201)41:3<494::AID-ANIE494>3.0.CO;2-S

Abstract

Similar to the classical β turn: An intramolecular cyclic 10-atom motif is defined in the molecular conformation of Piv-^lPro-γ-Abu-NHMe (see powder X-ray diffraction structure; Piv: pivaloyl, ^Lpro: L-proline, γ-Abu: γ-aminobutyric acid) by a C-H...O interaction. This study emphasizes the considerable potential of powder X-ray diffraction as an alternative to single-crystal X-ray diffraction.

Item Type:	Article
Source:	Copyright of this article belongs to John Wiley and Sons, Inc.
Keywords:	Hydrogen Bonds; Peptides; Powder Diffraction; Structure Elucidation; X-ray Diffraction
ID Code:	4552
Deposited On:	18 Oct 2010 07:32
Last Modified:	16 May 2016 15:11

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