On the dynamics of controlled metabolic network and cellular behavior

Sinha, Somdatta ; Ramaswamy, Ramakrishna (1987) On the dynamics of controlled metabolic network and cellular behavior Biosystems, 20 (4). pp. 341-354. ISSN 0303-2647

Full text not available from this repository.

Official URL: http://www.sciencedirect.com/science/article/pii/0...

Related URL: http://dx.doi.org/10.1016/0303-2647(87)90052-9


The existence of elaborate control mechanisms for the various biochemical processes inside and within living cells is responsible for the coherent behaviour observed in its spatio-temporal organisation. Stability and sensitivity are both necessary properties of living systems and these are achieved through negetive and positive feedback loops as in other control systems. We have studied a three-step reaction scheme involving a negative and a positive feedback loop in the form of end-product inhibition and allosteric activation. The variety of behaviour exhibited by this system, under different conditions, includes steady state, simple limit cycle oscillations, complex oscillations and period bifurcations leading to random oscillations or chaos. The system also shows the existence of two distinct chaotic regimes under the variation of a single parameter. These results, in comparison with single biochemical control loops, show that new behaviours can be exhibited in a more complex network which are not seen in the single control loops. The results are discussed in the light of a diverse variety of cellular functions in normal and altered cells indicating the role of controlled metabolic network as the underlying basis for cellular behaviour.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Model Reactions; Control Circuit; Chaos; Cell Behaviour
ID Code:45367
Deposited On:28 Jun 2011 04:42
Last Modified:28 Jun 2011 04:42

Repository Staff Only: item control page