Karle, Isabella L. ; Flippen-Anderson, Judith L. ; Uma, K. ; Balaram, P. (1988) Aggregation studies in crystals of apolar helical peptides: Boc-Aib-Val-Ala-Leu-Aib-Val-Ala-Leu-Aib-OMe International Journal of Peptide and Protein Research, 32 (6). pp. 536-543. ISSN 0367-8377
![[img]](http://repository.ias.ac.in/style/images/fileicons/application_pdf.png)
|
PDF
- Publisher Version
1MB |
Official URL: http://www3.interscience.wiley.com/journal/1216347...
Related URL: http://dx.doi.org/10.1111/j.1399-3011.1988.tb01385.x
Abstract
In the crystal, the backbone of Boc-(Aib-Val-Ala-Leu)2-Aib-OMc adopts a helical form with four α-type hydrogen bonds in the middle, flanked by 310-type hydrogen bonds at either end. The helical molecules stack in columns with head-to-tail hydrogen bonds, either directly between NH and CO, or bridged by solvent molecules. The packing of the helices is parallel, even in space group P21. Cell parameters are a = 9.837(2) Å. b = 15.565(3) Å. c = 20.087(5) Å, β= 96.42(2)°. dcalc= 1.091 g/cm3 for C46H83,N9O12· 1.5H2O·0.67CH3OH. There appears to be some hydration of the backbone in this apolar helix.
| Item Type: | Article |
|---|---|
| Source: | Copyright of this article belongs to Munksgaard International Publishers. |
| Keywords: | Aib Residues; 310-helix α-helix; Parallel Packing Of Helices; Crystal Structure; Head-to-tail Hydrogen Bonds; Hydration of Backbone |
| ID Code: | 4528 |
| Deposited On: | 18 Oct 2010 07:35 |
| Last Modified: | 16 May 2016 15:10 |
Repository Staff Only: item control page
