Levinthal's paradox

Zwanzig, R. ; Szabo, A. ; Bagchi, B. (1992) Levinthal's paradox Proceedings of the National Academy of Sciences of the United States of America, 89 (1). pp. 20-22. ISSN 0027-8424

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Official URL: http://www.pnas.org/content/89/1/20.abstract


Levinthal's paradox is that finding the native folded state of a protein by a random search among all possible configurations can take an enormously long time. Yet proteins can fold in seconds or less. Mathematical analysis of a simple model shows that a small and physically reasonable energy bias against locally unfavorable configurations, of the order of a few kT, can reduce Levinthal's time to a biologically significant size.

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Deposited On:18 Oct 2010 07:52
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