Zwanzig, R. ; Szabo, A. ; Bagchi, B. (1992) Levinthal's paradox Proceedings of the National Academy of Sciences of the United States of America, 89 (1). pp. 20-22. ISSN 0027-8424
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Official URL: http://www.pnas.org/content/89/1/20.abstract
Abstract
Levinthal's paradox is that finding the native folded state of a protein by a random search among all possible configurations can take an enormously long time. Yet proteins can fold in seconds or less. Mathematical analysis of a simple model shows that a small and physically reasonable energy bias against locally unfavorable configurations, of the order of a few kT, can reduce Levinthal's time to a biologically significant size.
| Item Type: | Article |
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| Source: | Copyright of this article belongs to National Academy of Sciences, USA. |
| ID Code: | 4442 |
| Deposited On: | 18 Oct 2010 07:52 |
| Last Modified: | 16 May 2016 15:05 |
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