Managing models of signaling networks

Bhalla, Upinder S. (2003) Managing models of signaling networks Neurocomputing, 52-54 . pp. 215-220. ISSN 0925-2312

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/S09252...

Related URL: http://dx.doi.org/10.1016/S0925-2312(02)00737-3

Abstract

Signaling pathways participate in complex information processing networks. These networks handle housekeeping functions of the cell as well as specialized functions such as synaptic plasticity. I report two developments in managing such networks: a compilation of mass-action kinetic models of signaling pathways, and shared motifs in the chemistry of interactions between signaling pathways. These motifs may prove useful in abstracting signaling networks, without compromising chemical reaction details. The combination of a library of signaling pathway models, and high-level rules to connect these pathways, may simplify development of complex signaling network models.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
Keywords:Mass-action Chemistry; Signaling Pathways; Simulation; Database
ID Code:4403
Deposited On:18 Oct 2010 14:11
Last Modified:16 May 2011 15:42

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