Solution conformations of penta and heptapeptides containing repetitive α-aminoisobutyryl-L-alanyl and α-aminoisobutyryl-L-valyl sequences

Vijayakumar, E. K. S. ; Balaram, P. (1983) Solution conformations of penta and heptapeptides containing repetitive α-aminoisobutyryl-L-alanyl and α-aminoisobutyryl-L-valyl sequences Tetrahedron, 39 (16). pp. 2725-2731. ISSN 0040-4020

Full text not available from this repository.

Official URL: http://linkinghub.elsevier.com/retrieve/pii/S00404...

Related URL: http://dx.doi.org/10.1016/S0040-4020(01)91984-2

Abstract

The presence of folded solution conformations in the peptides Boc-Ala-(Aib-Ala)2-OMe, Boc-Val-(Aib-Val)2-OMe, Boc-Ala-(Aib-Ala)3-OMe and Boc-Val-(Aib-Val)3-OMe has been established by 270MHz1H NMR. Intramolecularly H-bonded NH groups have been identified using temperature and solvent dependence of NH chemical shifts and paramagnetic radical induced broadening of NH resonances. Both pentapeptides adopt 310 helical conformations possessing 3 intramolecular H-bonds in CDCl3 and (CD3)2SO. The heptapeptides favour helical structures with 5 H-bonds in CDCl3. In (CD3)2SO only 4 H-bonds are readily detected.

Item Type:Article
Source:Copyright of this article belongs to Elsevier Science.
ID Code:4376
Deposited On:13 Oct 2010 11:39
Last Modified:16 May 2011 08:53

Repository Staff Only: item control page