Iqbal, M. ; Shivaji, S. ; Vijayasarathy, S. ; Balaram, P. (1980) Synthetic peptides as chemoattractants for bull spermatozoa structure activity correlations Biochemical and Biophysical Research Communications, 96 (1). pp. 235-242. ISSN 0006-291X
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Official URL: http://linkinghub.elsevier.com/retrieve/pii/000629...
Related URL: http://dx.doi.org/10.1016/0006-291X(80)91205-X
Abstract
The ability of various synthetic peptide analogs of Formyl-Met-Leu-Phe to induce chemotaxis in bull sperm is compared using an inverted capillary assay. The formyl group is essential for chemotactic activity and corresponding t-butyloxycarbonyl tripeptides are inactive. Sequence analogs, Formyl-Met-Phe-Leu, Formyl-Leu-Met-Phe and Formyl-Leu-Phe-Met are active. Replacement of Met and Leu by Pro does not diminish activity. Formyl-Met-Leu-Phe-NH2 is active suggesting that electrostatic interactions involving the carboxyl group may be unimportant in receptor interactions. The studies establish the importance of an amino terminal formyl group and a sequence of at least three hydrophobic residues, for inducing sperm chemotaxis.
Item Type: | Article |
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Source: | Copyright of this article belongs to Elsevier Science. |
ID Code: | 4325 |
Deposited On: | 18 Oct 2010 08:55 |
Last Modified: | 16 May 2016 14:59 |
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