Solid-phase synthesis and C-terminal amidation of peptides using a photolabile o-nitrobenzhydrylaminopolystyrene support

Ajayaghosh, A. ; Rajasekharan Pillai, V. N. (1995) Solid-phase synthesis and C-terminal amidation of peptides using a photolabile o-nitrobenzhydrylaminopolystyrene support Tetrahedron Letters, 36 (5). pp. 777-780. ISSN 0040-4039

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Official URL: http://linkinghub.elsevier.com/retrieve/pii/004040...

Related URL: http://dx.doi.org/10.1016/0040-4039(94)02366-J

Abstract

Synthesis of a new photolabile polymeric support (NBHA-resin) and its application in solid-phase synthesis of fully protected and unprotected C-terminal peptide amides are described. Peptide amides were obtained in high yields due to the better photocleavage efficiency of NBHA-resin compared to o-nitrobenzylamino-resins.

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