Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools

Greenbaum, Jason A. ; Andersen, Pernille Haste ; Blythe, Martin ; Bui, Huynh-Hoa ; Cachau, Raul E. ; Crowe, James ; Davies, Matthew ; Kolaskar, A. S. ; Lund, Ole ; Morrison, Sherrie ; Mumey, Brendan ; Ofran, Yanay ; Pellequer, Jean-Luc ; Pinilla, Clemencia ; Ponomarenko, Julia V. ; Raghava, G. P. S. ; van Regenmortel, Marc H. V. ; Roggen, Erwin L. ; Sette, Alessandro ; Schlessinger, Avner ; Sollner, Johannes ; Zand, Martin ; Peters, Bjoern (2007) Towards a consensus on datasets and evaluation metrics for developing B-cell epitope prediction tools Journal of Molecular Recognition, 20 (2). pp. 75-82. ISSN 0952-3499

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A B-cell epitope is the three-dimensional structure within an antigen that can be bound to the variable region of an antibody. The prediction of B-cell epitopes is highly desirable for various immunological applications, but has presented a set of unique challenges to the bioinformatics and immunology communities. Improving the accuracy of B-cell epitope prediction methods depends on a community consensus on the data and metrics utilized to develop and evaluate such tools. A workshop, sponsored by the National Institute of Allergy and Infectious Disease (NIAID), was recently held in Washington, DC to discuss the current state of the B-cell epitope prediction field. Many of the currently available tools were surveyed and a set of recommendations was devised to facilitate improvements in the currently existing tools and to expedite future tool development. An underlying theme of the recommendations put forth by the panel is increased collaboration among research groups. By developing common datasets, standardized data formats, and the means with which to consolidate information, we hope to greatly enhance the development of B-cell epitope prediction tools.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:B-cell Epitopes; Epitope Prediction; Algorithms; Immunology Databases; Data Standardization; Bioinformatics; Software Tools; Tool Development
ID Code:43100
Deposited On:10 Jun 2011 04:18
Last Modified:10 Jun 2011 04:18

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