Use of adult male bonnet monkeys (Macaca radiata) for testing the biological activity of gonadotropin releasing hormone and its analogues

Jagannadha Rao, A. ; Keri, G. ; Kotagi, S. G. ; Chakraborti, R. ; Shanmugavelu, B. ; Ravindranath, N. (1991) Use of adult male bonnet monkeys (Macaca radiata) for testing the biological activity of gonadotropin releasing hormone and its analogues Andrologia, 23 (1). pp. 79-83. ISSN 0303-4569

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Official URL: http://onlinelibrary.wiley.com/doi/10.1111/j.1439-...

Related URL: http://dx.doi.org/10.1111/j.1439-0272.1991.tb02505.x

Abstract

The effect of injecting agonistic and antagonistic analogues of gonadotropin releasing hormone analogues on serum testosterone levels was checked in adult and immature male bonnet monkeys. Of the agonistic analogues Buserelin, Ovurelin and D-Phe6 Gln8 GnRH were found to be most potent in increasing serum testosterone levels in the adult male bonnet monkeys. While 27-month-old monkeys responded well to des Gly10 GnRH, only marginal response was observed in the case of 15-month-old monkeys. Studies carried out with Ovurelin indicated that it was not effective in causing desensitization in adult monkeys. The antagonistic analogue was effective in blocking nocturnal surge of serum testosterone. Based on these studies it is suggested the adult male bonnet monkeys can be effectively used for testing the activity of GnRH analogues.

Item Type:Article
Source:Copyright of this article belongs to John Wiley and Sons.
Keywords:Testosterone; Serum Levels; GnRH-analogues; Monkey
ID Code:43027
Deposited On:09 Jun 2011 14:31
Last Modified:09 Jun 2011 14:31

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