Oestrogenic regulation and differential expression of WNT4 in the bonnet monkey and rodent epididymis

Deshpande, Shayu N. ; Vijayakumar, Govindaraj ; Jagannadha Rao, A. (2009) Oestrogenic regulation and differential expression of WNT4 in the bonnet monkey and rodent epididymis Reproductive BioMedicine Online, 18 (4). pp. 555-561. ISSN 1472-6483

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Official URL: http://www.rbmojournal.com/article/S1472-6483(10)6...

Related URL: http://dx.doi.org/10.1016/S1472-6483(10)60134-4

Abstract

A role for oestrogen in regulating fluid reabsorption in the monkey epididymis was recently demonstrated. Here, these studies are extended to identify potential oestrogen-regulated proteins in the cauda region of monkey epididymis treated with vehicle and oestrogen receptor antagonist (ICI 182780). Two-dimensional electrophoretic analysis was used to identify the proteins. The results indicated down-regulation of WNT4 in the ICI-182780-treated monkey cauda. In addition, the Wnt4 mRNA concentration was also reduced in the caput regions of ICI-182780-treated rats and oestrogen receptor knockout mice. WNT4 is a key regulator of gonadal differentiation in humans and mice and plays a pivotal role in early mouse embryogenesis. The results of the present study establish the presence of WNT4 in the monkey epididymis and its regulation by oestrogen, and suggest a role for WNT4 in maintaining epididymal homeostasis.

Item Type:Article
Source:Copyright of this article belongs to Reproductive Healthcare Ltd.
Keywords:Epididymis; Monkey; Oestrogen; WNT4
ID Code:43018
Deposited On:09 Jun 2011 08:08
Last Modified:09 Jun 2011 08:08

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