Thermal fluctuations in histone during denaturation

Nagapriya, K. S. ; Raychaudhuri, A. K. ; Shivashankar , G. V. (2007) Thermal fluctuations in histone during denaturation Journal of Nanoscience and Nanotechnology, 7 (6). pp. 2125-2128. ISSN 1533-4880

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In this paper, we address the issue of thermal fluctuations during the thermal denaturation of linker histone H1 which is the basic ingredient of chromatin assembly. We measure the thermal fluctuations using a sensitive nanocalorimeter based thermal fluctuation measurement set up which can measure fluctuations of the order of 1 part per billion. We find that the denaturation of the linker histone is not a simple process. It is characterized by cooling jumps (energy absorbing jumps) followed by slow dynamics which is followed by heating jumps (bursts of energy release).

Item Type:Article
Source:Copyright of this article belongs to American Scientific Publishers.
Keywords:Thermal Fluctuations; Histone; Denaturation
ID Code:42625
Deposited On:04 Jun 2011 12:39
Last Modified:04 Jun 2011 12:39

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